Published Research

The scientific professionals at HRS are documenting the latest progress in nutrient and lifestyle medicine Our renowned scientists and clinicians are actively published in recognized journals. A lot of articles from our expert group have been published in peer-reviewed journals. Look at the examples below to see how we take positions on the important role of nutrient and lifestyle medicine in improving health and aging.

 

     
    Thiemann E, Heger PW, Chang JL, Salunkhe K.
The special extract ERr 731 is save in acute and long-term treatment of climacteric complaints in perimenopausal women,
A0 Poster on July 27, 2017 at the International Conference on Science and Society: Biopiracy and Phytomedicine (ICSS 2017) Johannes Gutenberg University Mainz, Germany, July 24-28,2017
     
    Thiemann E, Heger PW, Chang JL, Salunkhe K.
The special extract ERr 731 is save in acute and long-term treatment of climacteric complaints in perimenopausal women,
Poster Abstract in Specific diseases and ailments, page 49, on July 27, 2017 at the International Conference on Science and Society: Biopiracy and Phytomedicine (ICSS 2017) Johannes Gutenberg University Mainz, Germany, July 24-28,2017
     
    Heger PW, Chang JL, Thiemann E, Salunkhe K.
The special extract ERr 731 alleviated anxietx and depression and improved quality of life in symptomatic perimenopausal women,
Abstract in Session 8: Neurological Disorders, page 37, on July 26, 2017 at the International Conference on Science and Society: Biopiracy and Phytomedicine (ICSS 2017) Hilton Hotel Mainz, Germany, July 24-28,2017
     
    Franco OH, Chowdhury R, Troup J et al.
Use of Plant-Based Therapies and Menopausal Symptoms, A Systematic Review and Meta-analysis, JAMA, 2016;315(23):2554-2563
     
    Chang L, Montalto M, Heger PW, Thiemann E, Rettenberger R, Wacker J
Rheum rhaponticum extract (ERr 731®) post-marketing data on safety surveillance and consumer complaints, Integrative Medicine, Vol 15, No. 3, June 2016, 34-39 PMCID: PMC4982646 
     
    Gründemann C. et al. 
Influence of Rheum rhaponticum, Cimicifuga racemosa and Trifolium pratense extracts on breast cancer cell proliferation, Zeitschrift fur Phytotherapie 2015; 36: 157-163
     
    Taylor M
Complementary and Alternative Approaches to Menopause, Endocrinology & Metabolism Clinics of North America Volume 44, issue 3, 2015, pp. 619-648
     
    Guico-Pabia C
ERr 731, an ERβ agonist, is efficacious in reducing menopausal symptoms: a real-world observational study, Poster submitted 2015 to National Conference of Nurse Practitioners in the US
   
    Ismail R et al.
Effects of herbal preparations on symptoms clusters during the menopause transition, Climacteric, Volume 18, Issue 1, 2015
     
    Konda V et al.
Efficacy of Rheum rhaponticum extract ERr 731® in alleviating vasomotor menopausal symptoms in an ovariectomized rat model, presented at the North American Menopause Society (NAMS) meeting on Oct 16th, 2014
     
    Raudsepp P
The antioxidative and antimicrobial properties of the blue honeysuckle (Lonicera caerulea L.), Siberian rhubarb (Rheum rhaponticum L.) and some other plants, compared to ascorbic acid and sodium nitrite, Food Control 31 (2013) 129-135
     
    Roberts H, Lethaby A,
Phytoestrogens for menopausal vasomotor symptoms: A Cochrane review summary, Maturitas 2014 Jun;78(2):79-81
     
    Lethaby A et al.
Phytoestrogens for menopausal vasomotor symptoms. Cochrane Database Sys Rev 2013;(12), Art. No.: CD001395
     
    Vollmer et al.
Extract ERr731® does not mimic estrogen stimulated growth of MNU-induced breast cancer in ovariectomized Sprague-Dawley rats, Cancer Res 2013;73(24 Suppl): Abstract nr P5-05-09
DOI https://doi.org/10.1158/0008-5472.SABCS13-P5-05-09
     
   

Struck Dorothee
Rhapontik-Rhabarber bei zyklischen Kopfschmerzen, Eine Kasuistik
Zeitschrift für Phytotherapie 2013; 34: 74-75

     

 

 

Heger PW. 
Rhapontikrhabarberwurzel-Extrakt ERr 731® bei Wechseljahresbeschwerden Zeitschrift fur Phytotherapie 2010; 31: 299-305

 

 

 

 

 

Kneis KC, Gandjour A.
Economic evaluation of Sinfrontal in the treatment of acute maxillary sinusitis in adults. Appl Health Econ Health Policy. 2009;7(3):181-91

 

 

 

 

 

Zabolotnyi DI, Kneis KC, Richardson A, Rettenberger R, Heger M, Kaszkin-Bettag M, Heger PW.
Efficacy of a complex homeopathic medication (Sinfrontal) in patients with acute maxillary sinusitis: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial. Explore (NY). 2007 Mar-Apr;3(2):98-109

 

 

 

 

 

Keiler AM, Papke A, Kretzschmar G, Zierau O, Vollmer G., 
Long-term effects of the rhapontic rhubarb extract ERr 731(®) on estrogen-regulated targets in the uterus and on the bone in ovariectomized rats., J Steroid Biochem Mol Biol. 2011 Sep 21

 

 

 

 

 

Vollmer G, Papke A, Zierau O. 
Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors. Chin Med 2010; 5: 7

 

 

 

 

 

Obi N, Chang-Claude J, Berger J et al. 
The use of herbal preparations to alleviate climacteric disorders and risk of postmenopausal breast cancer in a German case-control study. Cancer Epidemiol Biomarkers Prev 2009; 18: 2207–2213 

 

 

 

 

 

Papke A, Kretzschmar G, Zierau O et al. 
Effects of the special extract ERr 731® from Rheum rhaponticum on estrogen-regulated targets in the uterotrophy model of ovariectomized rats. J Steroid Biochem Mol Biol 2009; 117: 176–184

 

 

 

 

 

Marietta Kaszkin-Bettag, Günter Vollmer, Reinhard Rettenberger, Peter W. Heger
Rhapontikrhabarberwurzel zur Behandlung von menopausalen Beschwerden - Spezialextrakt ERr 731 schließt Lücke zwischen Hormonersatztherapie und bisher verwendeten pflanzlichen Präparaten 
Erfahrungsheilkunde, März 2009, Jahrgang 58, Heft 02, 70-77

 

 

 

 

 

Kaszkin-Bettag, Hasper, Rettenberger
Rhapontikrhabarber-Wurzel: Der Spezialextrakt ERr 731® ist ein hochwirksames pflanzliches Arzneimittel zur Behandlung bei klimakterischen Beschwerden 
Gyne Sonderdruck, Februar 2009, S. 1-8

 

 

 

 

 

Kaszkin-Bettag, Hasper, Rettenberger
Rhapontikrhabarber-Wurzel: Der Spezialextrakt ERr 731® punktet im Klimakterium 
Gyne, Februar 2009, S. 16-20

 

 

 

 

 

Kaszkin-Bettag M, Ventskovskiy BM, Solskyy S, Beck S, Hasper I, Kravchenko A, Rettenberger R, Richardson A, Heger PW.
Confirmation of the efficacy of ERr 731® in perimenopausal women 
with climacteric symptoms. 
Alternative Therapies in Health and Medicine; Jan/Feb 2009, Vol. 15, No. 1:24-34

 

 

 

 

 

Kaszkin-Bettag M, Hasper I, Heger PW.
Der Spezialextrakt ERr 731® aus der Rhapontikrhabarberwurzel bei menopausalen Beschwerden: Langzeitstudie bestätigt Wirksamkeit. 
Schweizer Zeitschrift für Phytotherapie 2008(5);8:9-12

 

 

 

 

 

Kaszkin-Bettag M, Beck S, Richardson A, Heger PW, Beer A-M.
Efficacy of the special extract ERr 731® from rhapontic rhubarb for menopausal complaints: 
A 6-month open observational study. 
Alternative Therapies in Health and Medicine; Nov/Dec 2008, Vol. 14, No. 6:32-38

 

 

 

 

 

Hasper I, Ventskovskiy BM, Rettenberger R, Heger PW, Riley DS, Kaszkin-Bettag M.
Long-term efficacy and safety of the special extract ERr 731® of Rheum rhaponticum in perimenopausal women with climacteric complaints. 
Menopause. 16(1):117-131, January 2009

 

 

 

 

 

Kaszkin-Bettag M, Richardson A, Rettenberger R, Heger PW.
Long-term toxicity studies in dogs support the safety of the special extract ERr 731® from the roots of Rheum rhaponticum. 
Food Chem Toxicol 2008;46:1608-1618

 

 

 

 

 

Beer A-M, Kneis KC, Rettenberger R, Heger PW, Kaszkin-Bettag M.
Wirksamkeit von Phytoestrol® N (Extrakt Rheum rhaponticum ERr 731®) bei klimakterischen Beschwerden: Ergebnisse einer sechs-monatigen, prospektiven Anwendungsbeobachtung mit Phytoestrol® N.
J. Menopause 2007;3:8-15

 

 

 

 

 

Möller F, Zierau O, Jandausch A, Rettenberger R, Kaszkin-Bettag M, Vollmer G.
Subtype-specific activation of estrogen receptors by a special extract of Rheum rhaponticum (ERr 731®), its aglycones and structurally related compounds in U2OS human osteosarcoma cells.
Phytomedicine 2007;14(11):716-726

 

 

 

 

 

Wober J, Möller F, Richter T, Unger C, Weigt C, Jandausch A, Zierau O, Rettenberger R, Kaszkin-Bettag M, Vollmer G.
Activation of estrogen receptor-beta by a special extract of Rheum rhaponticum (ERr 731®), its aglycones and structurally related compounds.
J Steroid Biochem Mol Biol. 2007;107:191-201

 

 

 

 

 

Letter to the Editor.
Kaszkin-Bettag M.
Menopause 2007 Jul-Aug;14:810.

 

 

 

 

 

Letter to the Editor.
Dören M.
The special extract ERr 731® of the roots of Rheum rhaponticum decreases anxiety and improves health state and general well-being in perimenopausal women.
Menopause 2007 Jul-Aug;14:810.

 

 

 

 

 

Kaszkin-Bettag M, Rettenberger R, Heger PW. Der Spezialextrakt ERr 731® aus der Wurzel des Rhapontikrhabarbers (Rheum rhaponticum): Wirksamkeit bei Kopfschmerz/Migräne und weiteren klimakterischen Beschwerden bei Frauen in der Perimenopause. 
Schweizer Zeitschrift für Phytotherapie 2007; 2:24-30.

 

 

 

 

 

Letter to the Editor: Reply.
Kaszkin-Bettag M.
Menopause 2007;14:336-337.

 

 

 

 

 

Letter to the Editor:
Prior JC, Seifert-Klauss, V, Kalyan S, Pride S.
Menopause 2007;14:335-336.

 

 

 

 

 

Kaszkin-Bettag M, Ventskovskiy BM, Kravchenko A, Rettenberger R, Richardson A, Heger PW, Heger M. The special extract ERr 731® of the roots of Rheum rhaponticum decreases anxiety and improves health state and general well-being in perimenopausal women. 
Menopause 2007;14:270-283.

 

 

 

 

 

Heger M, Ventskovskiy BM, Borzenko I, Kneis KC, Rettenberger R, Kaszkin-Bettag M, Heger PW. Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731®) in perimenopausal women with climacteric complaints: A 12-week randomized, double-blind, placebo-controlled trial. 
Menopause 2006;13(5): 744-759.

 

 

 

 

 

Vollmer G, Moeller F, Unger C, Wober J, Zierau O, Kaszkin-Bettag M. Activation of estrogen receptor-β by a special extract of Rheum rhaponticum (ERr 731®), its aglycones and structurally related compounds.
Proceedings of the 88th Annual Meeting of the Endocrine Society 2006, Boston, p. 282, P1-481

 

 

 

 

 

Möller F, Richter T, Unger C, Weigt C, Wober J, Zierau O, Rettenberger R, Kaszkin-Bettag M, Vollmer G. Activation of estrogen receptor-ß by a special extract of Rheum rhaponticum (ERr 731®), its aglycones and structurally related compounds.
Abstract zum Kongress der Deutschen Gesellschaft für Endokrinologie, 1.3. - 4.3.2006, Essen

 

 

 

 

 

Trends & Fakten: Phytoestrol® N - effektive und sichere Therapie bei klimakterischen Beschwerden.
Erfahrungsheilkunde 2005;6:431

 

 

 

 

 

Aus der Industrie: Phytoestrol® N wirkt effektiv bei klimakterischen Beschwerden. 
Frauenarzt 2005;46(6):522

 

 

 

 

 

Therapiereport: Phytoestrol® N - effektive und sichere Therapie bei klimakterischen Beschwerden. 
Ärztezeitschrift für Naturheilverfahren 2005; 46(7):453.

 

 

 

 

 

Phytos dämpfen klimakterische Beschwerden.
Ärztliche Praxis: Gynäkologie 2005; 4:31

 

 

 

 

 

PharmaNEWS: Pflanzliche Alternative gegen Hitzewallungen.
Ärztliche Praxis 2005;26:9

 

 

 

 

 

Industrie und Forschung - News: Pflanzliche Hilfe bei Klimakteriumsbeschwerden.
Der Hausarzt 2005;13:58

 

 

 

 

 

Klimakterische Beschwerden.
gyn - Praktische Gynäkologie 2005;4:264

 

 

 

 

 

Meldungen: Rhapontikrhabarberextrakt: Effektive und sichere Therapie bei klimakterischen Beschwerden. 
Gyne Oktober 2005:168.

     
   

Bachert C, Chuchalin AG, Eisebitt R, Netayzhenko VZ, Voelker M.
Aspirin compared with acetaminophen in the treatment of fever and other symptoms of upper respiratory tract infection in adults: a multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel-group, single-dose, 6-hour dose-ranging study. Clin Ther. 2005 Jul;27(7):993-1003.

     
   

Klein-Bischoff U, Kaszkin-Bettag M, Heger PW, Sökeland J
Wirksamkeit des Brennesselwurzel-Extraktes PU 240 bei BPH; Ergebnisse einer 24-wöchigen, offenen, multizentrischen, prospektiven Phase-IV-Studie
Therpie Report aktuell Nr.160; Uro-News Nr. 1-2/2007